Spectrométrie de masse

Edmond de Hoffmann, Vincent Stroobant

Mass spectrometry is a technique widely used throughout science for the identification of compounds, by producing, separating and detecting ions in the gas phase. A complete overview of the principles, theories and key applications of modern mass spectrometry are presented in this carefully structured text. All instrumental aspects of mass spectrometry are clearly and concisely described; sources, analysers and detectors. Tandem mass spectrometry is introduced early, and then developed in more detail in its own chapter. Emphasis is placed throughout the text on optimal utilization conditions. Various fragmentation patterns are described, along with the analytical information that derives from the mass spectra. The importance of applications is recognized, and this theme runs throughout the book, along with an entire chapter devoted to the analysis of biomolecules. Numerous examples and illustrations feature throughout, along with a series of exercises of increasing difficulty that help students fully to understand the subject. References to the original literature are provided for the reader who wants more detailed information, along with a list of books for further reading. Mass Spectrometry will be invaluable to undergraduates and postgraduates using this technique in departments of chemistry, biochemistry, medicine, pharmacology, agriculture and food science. It will also appeal to researchers looking for an introduction to this important technique.